The character appeared in specials and monthly titles detailing the afterlife of Elisa Cameron and her search for the truth surrounding her (apparent) death.

The stories in both series were based in (and around) the city of Arcadia, in a self-contained fictional universe outlined in Dark Horse's Comics' Greatest World.

Ghost continued appearing in her own titles (and others) into the 2000s, including several crossovers unrelated to Comics' Greatest World.

The series takes place in Arcadia, which is intended to be a grim, yet Art Deco city, as reflected in the artwork of the early issues.

Eliza appears to have lost her memory; she and the paranormal investigators she befriends cover up her self-defence killing and resolve to solve the mystery of her identity.

Dark Horse launched a third series, In the Smoke and Din, consisting of four issues published from September 2012.