Ghost Squad features a simulated IR light gun shaped similarly to the standard-issue weapon the game's protagonists use.

This light gun is intended to function realistically: it features a working fire selector switch, a stock, force-feedback recoil, and iron sights.

To ensure that the light gun fires accurately, a 20-second "calibration" mode is provided in which the game adjusts for any jostling or damage to the rifle's light-emitting components.

Ghost Squad features three semi non-linear levels with adjustable difficulty and branching choices (dubbed "Tactical Decisions"[5]), ranging from the jungle, a government-restricted villa, and inside an Air Force One flight.

There are many sub-activities in the game, such as defusing bombs and throwing grenades to disable armor, which are accomplished via the secondary "Action" trigger on the gun's foregrip.

Special events occur throughout the game depending on the route chosen, such as securing hostages, bomb removal, or providing friendly cover fire.

In addition, the game features a pointer calibration mode, enabling players to use line-of-sight aiming and fire precisely where the Wii Remote is pointed.

[8] IGN gave it a 7.5, remarking that "most of what made Ghost Squad fun in the arcades is still retained though, as there's a huge emphasis on weapon management and mid-level missions.