The shooting of his last film, Pakeezah, was held up for many years due to marital and personal problems between the film producer Kamal Amrohi and the lead actress Meena Kumari, and was finally released only after Ghulam Mohammed's death.

He eventually signed on as a contract artiste for 25 rupees a month, but before he could take up the appointment, the theatre closed due to financial difficulties.

In 1924, he came to Bombay, where after a struggle of eight years, in 1932 he got the chance of playing tabla in Saroj Movietone's Productions' "Raja Bharthari".

Arriving bang in the midst of the peak era of R. D. Burman and Kishore Kumar, it brought back classic melody of the timeless kind and won a Gold Disc from Saregama, which was then called HMV, for outstanding sales."

"One commonly-heard story is that when Shankar–Jaikishan were composing their maiden venture Barsaat (1949), they insisted on having Ghulam Mohammed play the dholak for the film song 'Barsaat Mein Ham Se Mile Tum Sajjan'".