Francia was trained by his father in painting and goldsmithing, and acted as his assistant.
In 1517, the year of his father's death, he and his brother, Giulio, assumed responsibility for the family business and together executed many church altarpieces, identifiable by the initials (I I) of their Latinized names (Iacobus and Iulius).
Late in life Giacomo came under the influence of Dosso Dossi.
[1] Giacomo's earliest known work is the Virgin in Glory with Saints Peter, Mary Magdalene, Francis, Martha and Six Nuns (after 1515; Pinacoteca Nazionale, Bologna, ).
In this painting, as in the Saints Jerome, Margaret and Francis (1518; Madrid, Prado) and the Nativity (1519; San Giovanni Evangelista, Parma), both dated and signed by both brothers, there appear, in addition to the influence of their father, echoes of the monumental style of Raphael.