He launched his sprint 300 m (980 ft) away from the finish, and was almost passed on the line by Jürgen Roelandts (Lotto–Belisol), who thought he had won, but the photo-finish would prove that Nizzolo was the victor.

[5] He won the Points classification in the Giro d'Italia two years in a row in 2015 and 2016 without a stage win.

In 2018 Nizzolo was named as a rider in the Vuelta a España, he finished on the podium on 3 different stages.

Nizzolo signed a two-year contract with Team Dimension Data on 21 September 2018; this marked the first time Nizzolo had changed teams in his professional career.

[6] In July 2019, he was named in the startlist for the Tour de France.