Giacomo Puteo was born in Majorca on 13 February 1495, the son of noble Antoni del Pozzo (from Nice, native of Alessandria, Piedmont) and Praxedis Berard i Caulelles.
[1] He received the red hat and the titular church of San Simeon in Posterula on 4 December 1551.
[1] During the pontificate of Pope Paul IV, he was Prefect of the Apostolic Signatura; a member of the Supreme Sacred Congregation of the Holy Office; and was cardinal protector of both the Kingdom of Poland and the Sovereign Military Order of Malta.
[1] Together with Cardinal Giovanni Battista Cicala, he was charged with examining abolishing the alienation of ecclesiastical patrimony done against the constitution of Pope Paul II.
[1] On 16 December 1562 he resigned the government of Bari in favor of his nephew Antonio del Pozzo.