He was a close advisor of Silvio Berlusconi and is a member of the advisory board of Goldman Sachs International.

He was editor-in-law of Il Tempo from 1973 to 1987; that year, he left the newspaper in order to enter into the Fininvest group owned by Silvio Berlusconi.

[2] In 2006, Berlusconi nominated him as the House of Freedoms candidate to succeed Carlo Azeglio Ciampi as President of the Italian Republic.

He received the votes from the right-wing coalition but he was soundly refused by the majority of the house, L'Unione, for being considered as the factotum of Silvio Berlusconi.

On 18 June 2007, Letta was made a member of the advisory board of Goldman Sachs International, assigned by the bank to "provide strategic consulting on growth opportunities, with a special focus on Italy.