[3] Mantzourakis began his youth football career with Şcoala Sportivă 2 București where he met Mircea Lucescu who was three years older than him.
[4] He made his senior debut in Cluj-Napoca the birthplace of his mother playing for CFR Cluj in the Romanian Second Division in 1967.
[6] In 1970, he moved to Greece and played for PAOK winning the Greek Cup in 1972 and later he was transferred to AEL, where he spent the most of his career.
Mantzourakis was signed by Spanish Segunda División side, Terrassa in the 1975–76 season, but unfortunately didn't get to play any match.
On 9 April 2000, the day of the Greek parliament elections, Olympiacos' chairman Sokratis Kokkalis sacked manager Alberto Bigon.
In the summer transfer period, Zlatko Zahovic was transferred to Valencia FC, although other high-class players, such as Ze Elias, Grigoris Georgatos (on loan from Inter), Par Zetterberg, Christian Karembeu, Gabriel Alvez and the young Nery Castillo, moved to Olympiacos.
With these additions, Matzourakis' team became more powerful and celebrated wins over Olympique Lyonnais (2–1) and Valencia FC (1–0) at home in the 2000–01 Champions League.
Although, Olympiacos was unable to win away, and due to a loss to Heerenveen S.C. 1–0 in the Netherlands, the Greek champions finished 3rd with 9 points and failed to qualify to the second round.
This, along with an argue with Lampros Choutos, forced Matzourakis to leave the club, while Olympiacos was first in the league, 4 points over Panathinaikos and AEK.
He returned to Cyprus in January 2007, this time for AC Omonia, replacing their previous coach Ioan Andone without success.
He managed to achieve promotion to the Superleague, as well as securing relegation-safe status in the club's first season in the competition, despite playing all home games at neutral ground.
The next season however, the club's board of directors surprisingly terminated Mantzourakis' contract in mid-season[10] in favour of Vangelis Vlachos, who was hired a day later.
In this short period, he coached the club in two crucial competition matches, recording a draw against Panionios and a loss against Atromitos.