His second season was a very impressive one, catching the eye of major Greek teams in 2007–08, which eventually earned him a move to Olympiacos on 3 June 2008.

On 5 October 2008, Papadopoulos became a man as he made his Olympiakos debut as a substitute for teammate Dudu Cearense against city rivals AEK Athens.

He made his debut with the club on 17 March in a 1–0 home win against Jagiellonia Białystok and a week later he scored the only goal in a 1–1 away draw against Podbeskidzie Bielsko-Biała.

On 11 July 2014, Papadopoulos signed a one-year contract with the Israeli football club Bnei Sakhnin F.C.

As a result of this outstanding performance one of the biggest sports' sites in the country («sports.walla») indicate that his acquisition was crucial for the club, a fact that is also acknowledged from the team coach, Shlomi Dora, who in an interview he gave on the same site asked what were the five key moments of the year and of course stated that the acquisition of the Papadopoulos is one of them.

[6][7] On 16 July 2015 signed to Hapoel Kfar Saba[8] On 20 December 2015, he scored his first goal in the season, helping his club to escape with a 1–1 draw against Maccabi Haifa.

On 30 April 2016, he scored with an incredible left kick in a 2–1 home win against Ironi Kiryat Shmona.