[1] Precisely on behalf of his uncle-doge he fought between 1436 and 1437 in the Alessandrian domains of the Republic of Genoa conquering the local castle of Voltaggio, destroying the troops of the Duchy of Milan of Filippo Maria Visconti and other victorious clashes in Gavi.

The Corsican chronicles will testify to a decidedly negative and power government by Fregoso, but these reports, also in the opinion of the historians themselves, should however be sought in the well-known bad coexistence and hostility between the locals and the Genoese dominion on the island that have always generated clashes or different interpretations of the facts.

Refugee in Corsica to avoid a probable imprisonment by Adorno, he found on his arrival on the island a situation unfavorable to him consequently to the fresh appointment of the two new Genoese governors, Antonio and Nicolò Montaldo, who, in fact, took his place .

A peace treaty was signed with Duke Visconti (1444), he moved from the Sarzana family fiefdom to Nice where he made an agreement (1446) with the ambassadors of Charles VII of France, bartering the submission of the Genoese republic in exchange for economic or financial aid.

The unfavorable situation for the new Doge changed, however, little by little with the death of Filippo Maria Visconti, who, due to a dispute over the succession, "messed up" the international chessboard and looked away at Genoa.

The relationship with Galeotto Del Carretto, lord of the Marquisate of Finale was more difficult and contrasted, which during the Campofregoso's Dogate repeatedly plundered and attacked several centers and territories controlled by the Genoese republic.

The doge also sought a peaceful agreement, even combining marital ties, which eventually became a clash in the end of 1447 and the beginning of 1448 when two armed ships and an army of 8000 soldiers were sent to the Finale Ligure under the command of his cousin Pietro di Campofregoso.