Children as young as 1.5 months and up to 12 years of age are reported to be affected.

[9] It is generally recognized as a papular or papulovesicular skin rash occurring mainly on the face and distal aspects of the four limbs.

A validated diagnostic criterion[10][11][12] is as follows: A patient is diagnosed as having Gianotti–Crosti syndrome if: The positive clinical features are: The negative clinical features are: The differential diagnoses are: acrodermatitis enteropathica, erythema infectiosum, erythema multiforme, hand-foot-and-mouth disease, Henoch–Schönlein purpura, Kawasaki disease, lichen planus, papular urticaria, papular purpuric gloves and socks syndrome, and scabies.

[citation needed] Gianotti-Crosti disease is a harmless and self-limiting condition, so no treatment may be required.

[13] Treatment is mainly focused on controlling itching, symptomatic relief and to avoid any further complications.