Weed took part in the anti-Northern Pacific agitation and was an officer in the Home Guards during the anti-Chinese riots in Seattle.

Weed, a medical doctor by profession is credited with greatly reducing the impact of a smallpox epidemic in 1877, acting as the city's health officer and even paying for treatment of patients from his own pocket.

He was married to Adaline M. Weed, who was born in Illinois and moved to the west coast after her marriage to Gideon in New York in 1857.

"A Wedding on Hydropathic Principles" took place between Gideon Allen Weed and Adaline M. Willis.

Classmates at Trall's Hygeio-Therapeutic College described that they "have now united in hands, hearts, fortunes and diplomas."