The Herborn architect, Ludwig Hoffmann was in charge of planning and executing the station.

[5] During the Second World War the building was damaged and the Fürstenbahnhof (princely station) located in the northern wing was destroyed in 1944.

The station building is listed as a historic landmark under the Hessian Monument Protection Act.

The main objective of the work was the building of a new pedestrian underpass and the provision of barrier-free access to all platforms.

After delays due to the long and severe winter, the new building was opened on 21 July 2010, when platform tracks 12–15 could be reached by the new underpass.

[6] The Giessen train station has eleven station platform tracks in its two sections: Giessen is part of the German Intercity-Express network with ICE trains operating on the Main-Weser Railway bi-hourly between Karlsruhe, Hamburg and Sylt or the baltic coast.

At that time local freight trains operated from here to several stations in the area (e.g. Frankenberg (Eder), Dillenburg and Nida).