[1] It gives rise to the lateral (medullary) reticulospinal tract which influences muscle tone of limb and trunk muscles, is involved in coordination of head-eye movements, promotes parasympathetic reduction of heart rate to decrease blood pressure, induces inspiration, and participates in the descending pain-inhibiting pathway.
[citation needed] It receives afferent corticoreticular fibers from the premotor cortex and supplementary motor area which modulate the activity of reticulospinal and reticulobulbar efferents.
[1] It gives rise to the lateral (medullary) reticulospinal tract (which excites flexors and inhibits extensors of the muscles of the axial and proximal limbs).
[1] The GGRN forms part of the vasodepressor center which projects through the reticulobulbar tract to synapse upon pre-ganglionic parasympathetic neurons of the nucleus of vagus nerve.
[1] The GGRN - together with the nucleus raphe magnus - gives rise to the descending serotonergic raphespinal tract which projects to the spinal cord to inhibit transmission of pain stimuli.