Since coming to attention hosting Hulu's daily pop culture show The Morning After (2011–12), she has had numerous guest and recurring roles on television and has been in the main cast of such series as Mixology, Wrecked, and She-Hulk: Attorney at Law.

[2] Gonzaga graduated a year early to train at The Groundlings school, and went on to study improv at Second City and Upright Citizens Brigade.

[3] Gonzaga hosted Hulu's comedic daily pop culture recap show The Morning After.

She has also appeared in numerous other television shows, including Togetherness, I'm Dying Up Here, Wrecked, Kidding, and Room 104.

[8][9] Gonzaga portrays Helen Tasker in the 2023 CBS series adaptation of the 1994 film True Lies.