Gino Iorgulescu was born on 15 May 1956 in Giurgiu, Romania and started to play junior level football at local club, Dunărea, making his debut for the senior squad in the 1973–74 Divizia B season.

[3][4][5] He was transferred alongside Dunărea teammate, Calianu at Sportul Studențesc București where he made his Divizia A debut under coach Angelo Niculescu on 31 August 1975 in a 1–1 against Universitatea Craiova, that being his only appearance in that season, being used more by Mircea Rădulescu at the team's youth squad and in the next season he was loaned at fellow Divizia A team, Progresul București where he made 28 appearances with 6 goals scored, afterwards returning at Sportul Studențesc when Rădulescu became the coach of the senior squad and used him more often.

[3][4][5][6][2] Gino Iorgulescu played 48 games and scored two goals at international level for Romania, making his debut on 11 November 1981 under coach Mircea Lucescu in a 0–0 against Switzerland at the 1982 World Cup qualifiers.

[1][6] Iorgulescu's last appearance for the national team took place on 8 October 1986 when coach Emerich Jenei sent him on the field in the 80th minute in order to replace Gheorghe Hagi in a 4–2 away victory in a friendly against Israel.

[15] After he retired from his playing career, Gino Iorgulescu started working as an assistant at Romania's national team of Mircea Rădulescu in 1990, his coach from Sportul Studențesc.