His design thesis in his senior year was a complete redesign of a used Fiat Topolino, in which he modified the engine for increased power and relocated it in the chassis for improved handling.

After graduation, he taught briefly before joining Alfa Romeo's 'Servizio Esperimenze Principali' unit under Ing.

He was assigned to the development of the Alfa Romeo Giulietta chassis, which was disappointing, as he aspired to become a powerplant engineer.

For one of the most successful Ferrari racing series, the 250, Bizzarrini worked hard to develop the chassis, engines, and advanced dynamic solutions.

'The Monster')[citation needed] Experiments with the SWB chassis indicated considerable speed loss due to aerodynamic drag, so Bizzarrini reduced the frontal area and increased the bonnet length, to reduce both drag and tendency to front lift at high speeds.

Bizzarrini moved the engine well back into the chassis and lowered it (by using a dry sump lubrication system) to improve weight distribution and handling.

In 1962, Bizzarrini was hired by Count Giovanni Volpi, owner of the Scuderia Serenissima Republica di Venezia, to upgrade a Ferrari 250 GT SWB (chassis number 2819GT) to GTO specification.

Bizzarrini applied all the ideas from the GTO and developed with Piero Drogo of Carrozzeria Sports Cars in the Modena works an aerodynamically advanced body, even lower than the GTO, with the roof line dramatically extended to the rear end, then abruptly truncated following the Kamm aerodynamic theory.

The mechanicals were extensively reformed and the engine set well back into the chassis and lowered, using dry-sump lubrication.

At least another two 250GT series cars were developed by Bizzarrini, Piero Drogo, and Neri and Bonacini to GTO specifications and received distinctive bodies with similar advanced shapes.

Giugiaro's Italdesign was founded on 13 February 1968, with a forty-day target to build their first design based on the Bizzarrini Grifo racing car with a deadline date for the Turin Motor Show in April.

[4] After Bizzarrini SpA, Giotto Bizzarrini also developed advanced designs for other companies, including American Motors for which he built prototypes for the AMX/III project, and as style and technical consultant for General Motors in Europe and USA, top Japanese motorcycle marques, and well-known designer marques such as Pininfarina.