Giovanni Cagliero SDB (11 January 1838 – 28 February 1926) was an Italian prelate of the Catholic Church who worked as a missionary in South America and served as Apostolic Delegate to Costa Rica, Honduras, and Nicaragua from 1908 to 1915 when he was elevated to the rank of cardinal.

On 30 October 1884, Cagliero was appointed Titular Bishop of Magydus by Pope Leo XIII, receiving his episcopal consecration on the following December 7 from Cardinal Gaetano Alimonda.

After being promoted to Titular Archbishop of Sebastea on 24 March 1904, he served as Apostolic Visitor to the dioceses of Bobbio, Piacenza, Savona, and Tortona in 1904.

[3] Pope Benedict XV made him Cardinal-Priest of San Bernardo alle Terme in the consistory of 6 December 1915.

[2] He was initially buried in the sepulchre of the Sacred Congregation for the Propagation of the Faith in Campo Verano cemetery, but his remains were transferred in 1964 to Mater Misericordiae Cathedral in Viedma.