During his dogal two-year period he preferred to start a situation of impartiality and economic neutrality and, consequently, also political both with the Kingdom of France and with the Spanish Empire.

In his mandate, moreover, he started negotiations and purchases for some fiefs of the Genoese and the Ligurian region originally in the hands of the Spinola and Doria dynasties.

[1][2] The official investiture of the Virgin Mary dates back almost to the end of its managementas "Queen and protector of Genoa", followed by a solemn religious and state ceremony for the coronation of the new statue depicting the Madonna which was positioned inside the Cathedral of San Lorenzo and adorned with the royal crown, the scepter and the keys of the city.

It was Doge Brignole Sale himself who handed over to the Genoese archbishop Giovanni Domenico Spinola such "state" effigies for the Virgin amid the ringing of festive bells and cannon shots.

[2] The dogate ceased on 11 July, the former doge Giovanni Francesco Brignole Sale died in Genoa in 1637.