[4] After a chance meeting with Ruggero Deodato's mother-in-law, he became acquainted with the director, and after a successful audition was cast in his 1980 horror film The House on the Edge of the Park.

Throughout the 1980s, Radice appeared in many Italian cult films such as Cannibal Apocalypse (1980), City of the Living Dead (1980), Stage Fright (1987) and The Church (1989).

Radice is best known for his villainous roles in Italian horror films, and notably for the spectacular and gruesome death scenes his characters semi-regularly fall victim to.

[5][6] In several interviews, he reportedly stated that he wished he had never portrayed Mike Logan in Cannibal Ferox, criticizing the movie for being both fascist and racist and abusive towards animals.

Lombardo Radice died on 27 April 2023, at the age of 68,[9] the same day as his Cannibal Apocalypse co-star Ramiro Oliveros.