Girls of the Big House is a 1945 American drama film directed by George Archainbaud and starring Lynne Roberts, Virginia Christine and Marion Martin.

Under an assumed name, Jeanne Crail, she is imprisoned with inmates including Bernice Meyers, who misses her boyfriend Smiley, and the condemned Alma Vlasek, who killed a policeman while waiting to ambush her cheating husband and his mistress.

When her man Smiley visits prison, Bernice is infuriated by his attraction to Jeanne and attacks her with a knife.

Alma, finally realizing who her husband's secret lover was, murders Bernice in the prison.

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