Giuseppe Antonio Ermenegildo Prisco (8 September 1833 – 4 February 1923) was an Italian cardinal of the Roman Catholic Church who was Archbishop of Naples.

He was ordained to the priesthood in September 1856 with an indult because he had not yet reached the canonical age for the appointment.

He was later served asa professor of rational law at Ospizio Ecclesiastico di Maria, Naples.

He was created cardinal deacon of S. Cesareo in Palatio by Pope Leo XIII in the consistory of 30 November 1896, receiving his red biretta on 3 December.

He was appointed as Archbishop of Naples on 24 March 1898 and was consecrated on 29 May 1898 in the Sistine Chapel by Pope Leo XIII.