Giuseppe Guerini (born 14 February 1970) is a retired Italian professional road bicycle racer.

He was known throughout his career as a climbing specialist and had pronounced success in cycling's Grand Tour events.

He is also remembered for an incident during the difficult Alpe d'Huez stage of the 1999 Tour de France.

Guerini was leading the field and only a few hundred meters from the finish line when a cycling fan knocked him off his bicycle while attempting to take a photograph.

Guerini was able to remount his bicycle and finish 21 seconds ahead of Pavel Tonkov.