His parents were Domenico and Paola Enrichetta Fogliazzi Manfredi and he had a brother, Enrico, and a sister, Maria Anna.

Over the next few years he became interested in politics and expressed his views about democratic philosophies in the newspaper Il Tribuno del popolo (English: Tribute of the People) and in pamphlets.

[1] Due to the things that Manfredi had written beginning in 1848, he was banned from practicing law by Charles III, Duke of Parma (who died in March 1854).

During the War of 1859, he coordinated the volunteers and kept in contact with La Farina, Manfredo Fanti, and Luigi Carlo Farini.

He married Paolina Giuditta Bertani in 1852 and they had six children, Philip, Clara, Vittorio Emanuele Manfredo, Ernestino and Leopold.

Paolina died in April 1877, and he subsequently married Countess Maria Carmela Giannerini, with whom he had four children, Corrado, Marcello, Anna, and Luis.

[1][2] In the commemoration by the Senate, he was described as follows, Noi tutti ne rammentiamo il nobile e caro sembiante, i modi affabili, la parola solenne, il cuore affettuoso, l'animo candido e puro, l'amor di patria ardente — which roughly translates to "We remember the noble and dear countenance, an affable manner, the solemn word, an affectionate heart, the candid and pure soul, ardent love of country.