From 1980 until 2010 Sacco was a professor at the Faculty of Political Sciences of the Libera Università Internazionale degli Studi Sociali Guido Carli,[1] where he taught International Relations and World Economic Systems, Development Sociology and International Migrations.

In 2006 he was in charge of the Research program of the Ministry of Education, Universities and Research of Italy,[8] in 1992 he was the director of the research project on "Immigration and Security Problems in Western Europe for the Italian Military Centre for Strategic Studies";[9] in 1991, he was the director of the "Feasibility Study on Solar Energy Production in the Sahara Region" in Algiers; in 1989, he was the director of economic and social studies "The Moscow Techno-park Project" at the Russian Academy of Sciences; in 1984 he was head of a mission for three feasibility studies in Malaysia for the Istituto nazionale per il Commercio Estero (ICE; National Institute for Foreign Trade)(furnishings, prefabricated building components, advanced technologies for food conservation); and in 1981 and 1982, he was the director of the ICE feasibility study on the setting up of a fish-farming plant on Lake Habbaniya (Iraq).

In the last decade he focused his attention on Chinese development and the outcome on USA, Europe and the global economy.

His latest work is "Batman and Joker: the Self Representation of America" Published in Italy and soon to have a second edition in printing.

Sacco wrote and contributed to several international revues, such as: New Society, Géopolitique,[12] Preuves, Commentary,[13]Internationale Politik, The International Spectator,[14] Commentaire,[15][16][17][18][19] The Washington Quarterly,[20] Politica Exterior,[21] Politique Etrangère,[22][23] Sociétal,[24][25][26] Outre-Terre[27] and Limes,[28] The Wilson Quarterly[29] and Lettera Internazionale.