They play in the Superliga Profesional de Baloncesto (SPB), the top-flight league in the country.

Currently, Gladiadores also play in the Basketball Champions League Americas (BCLA).

[1] The team was founded on 3 February 2019 as Gladiadores de Oriente, and joined the Venezeluan Serie A in their debut season.

[1] On 7 July 2023, Gladiadores won their first SPB championship, after defeating Guaros de Lara 4–1 in the Grand Final series.

[5] On 17 December 2023, Gladiadores became the first Venezuelan team to play in the BCL Americas.