While performing in Los Angeles, they were noticed by producer Edward Small, which led to her beginning in the film industry.

[2] Blake made her film debut in a small role in I Have Lived (1933), directed by Richard Thorpe.

[6] Appearing mostly in supporting or bit parts, she was occasionally given a featured role, as in Lucky Night (1939), which starred Myrna Loy and Robert Taylor;[7] or Woman of the Year (1942), which starred Spencer Tracy and Katharine Hepburn, in which she played Flo Peters, the wife of a friend of Tracy's character.

[9] In the early 1940s, she played the recurring role of "Maisie" in several of the Dr. Kildare films starring Lew Ayres, Lionel Barrymore, and Laraine Day.

[19] Blake's final role was in 1952's This Woman is Dangerous, starring Joan Crawford and Dennis Morgan, in which she plays a garrulous hairdresser.