Glasco is a city in Cloud County, Kansas, United States.

[3] Glasco was originally called Del Ray, and under the latter name was laid out and platted in 1870.

[6] This small town has two items of interest on the National Register of Historic Places: Pott's Ford Bridge is located just 1/2 mile south of the city limits, and the entire downtown business district has also earned a listing on the register.

According to the United States Census Bureau, the city has a total area of 0.33 square miles (0.85 km2), all land.

[7] The climate in this area is characterized by hot, humid summers and generally mild to cool winters.

[8] The 2020 United States census counted 441 people, 188 households, and 101 families in Glasco.

36.7% of households consisted of individuals and 20.2% had someone living alone who was 65 years of age or older.

31.2% of all households were made up of individuals, and 14.7% had someone living alone who was 65 years of age or older.

The racial makeup of the city was 98.32% White, 0.19% Native American, 0.19% Asian, and 1.31% from two or more races.

The community is served by Southern Cloud USD 334 public school district.