Gleisi Helena Hoffmann ([ˈɡlejzj ɛˈlẽnɐ ˈʁɔfmɐ̃]; born 6 September 1965) is a Brazilian lawyer and politician.

Following her tenure as Chief of Staff, she became a Senator for Paraná and in 2017 became national president of the Workers' Party.

Gleisi Hoffmann began her involvement in politics in the student movement during her youth, becoming a Workers' Party' member in 1989.

She was a member of Luiz Inácio Lula da Silva's presidential transition team in 2002, and served as the financial director at the Itaipu Binacional hydroelectric dam from 2003 to 2006.

She ran for the Federal Senate of Brazil in 2006 and for the office of mayor of Curitiba in 2008, losing both elections.