The Strabane and Letterkenny Railway was a 3 ft (914 mm) narrow gauge railway line between Strabane, County Tyrone and Letterkenny, County Donegal in Ireland.

It was the last railway constructed by the CDRJC bringing the network operated by this company to 121 miles.

The company pioneered the use of diesel operated railcars, but despite this innovation, closure came at the end of 1959, and the railway was shut to passengers on 1 January 1960.

[3] The line was used heavily by freight traffic between the market town of Letterkenny and Strabane.

The company continued to exist until 10 July 1971 when it was nationalised along with the County Donegal Railways Joint Committee by CIÉ.