He is the head football coach at the University of St. Thomas in Saint Paul, Minnesota, a position he had held since the 2008 season.

[4] After hearing that his son wouldn't live until his fifth birthday, Frank Caruso drove his family to the Basilica of Sainte-Anne-de-Beaupré to pray for healing; Glenn ended up recovering from the disease.

He considered law school, but eventually was hired by North Dakota State head coach Bob Babich.

In his first season at St. Thomas, in 2008, Caruso led the Tommies to a 7–3 record after the team had finished 2–8 the previous year.

In 2022, the second season of being a Division I program, 17 months into the transition, Caruso led St. Thomas to an undefeated conference championship.