A graduate of the Edmund A. Walsh School of Foreign Service at Georgetown University in Washington, D.C., he volunteered on medical education missions to the Middle East while in college.

[1] Nye was then posted to the U.S. Embassy in Singapore, where he helped protect U.S. intellectual property rights during the negotiation of the U.S.-Singapore Free Trade Agreement.

From there he volunteered to go to Afghanistan, spending almost a year as part of a U.S. government sponsored team managing the historic Afghan Constitution Commission and supporting the country's first presidential election.

He served as Operations Director in the Middle East by registering eligible voters in major U.S. cities for Iraq's Transitional National Assembly election.

Nye's donations from national Democrats, including House Speaker Nancy Pelosi of California, Majority Leader Steny Hoyer of Maryland and Representative Charles Rangel of New York, reflected the interest of the party in his race.

[15] Nye joined with 43 other Democrats to vote against the American Clean Energy and Security Act[16] in June 2009, and in November 2009, Nye voted along with 38 other Democrats against the Affordable Health Care for America Act,[17] saying that the bill did not do enough to reduce health care costs, and that it cut too much money from children's hospitals.

[20] In March 2011 Glenn Nye accepted a position at the German Marshall Fund where he helped facilitate communications between the United States and Europe.

[24] In December 2013, Glenn Nye became a trustee at the Center for the Study of the Presidency and Congress (CSPC), a non-partisan, non-profit Washington, D.C., think tank.