He played numerous small parts in Paramount's popular Hopalong Cassidy film series, usually cast as a member of an outlaw's gang and occasionally as a local sheriff.

[7] Strange appeared twice as Jim Wade on Bill Williams's syndicated Western series geared to juvenile audiences The Adventures of Kit Carson.

In 1952, he was cast in the role of Chief Black Cloud in the episode "Indian War Party" of the syndicated The Range Rider.

In 1954, Strange played Sheriff Billy Rowland in Jim Davis's syndicated Western series Stories of the Century.

That same year, Strange appeared in an uncredited role as the sheriff in Silver Rapids in the Western movie The Fastest Gun Alive starring Glenn Ford.

That same year, he played rancher Pat Cafferty, who faces the threat of anthrax, in the episode "Queen of the Cimarron" of the syndicated Western series, Frontier Doctor.

"[3] During Gunsmoke's sixth season, Strange played a Long Branch customer in "Old Faces" and a cowboy in "Melinda Miles".

I know I wished him lots of luck... hoping it would do as much for him as it did for me, but..."[11] Previously to House of Frankenstein, Strange starred as Petro, who is turned into a wolf-monster by George Zucco, in The Mad Monster (1943).

During the wave of monster-related merchandising in the late 1950s and 1960s, Glenn Strange's iconic image often was used for the monster on toys, games, and paraphernalia, most often from his appearance in the Abbott and Costello film.

In 1969, The New York Times mistakenly published Boris Karloff's obituary with Glenn Strange's picture as the Frankenstein monster.