2nd whaling voyage (1818–1820): Captain Gardner sailed from Nantucket on 3 March 1818, bound for the Pacific.

3rd whaling voyage (1820–1822): Captain George W. Gardner sailed from Nantucket on 9 August 1820, bound for the Pacific.

On his return, Captain Gardner transferred to the newly built and larger whaler Maria and thus was not her master on Globe's fourth voyage.

[5] On 22 December 1822, Globe, with a complement of 21 men under the command of Captain Thomas Worth, set sail on a whaling expedition to the Pacific.

"[6] Captain Worth took on seven new crew, four of whom (Silas Payne, John Oliver, William Humphries and Joseph Thomas) played major roles in the mutiny.

In an atmosphere of distrust existing between the mutineers, Payne and Oliver made an error in judgment by sending Gilbert Smith, a boatsteerer, to secure Globe.

Smith and five other crew cut the anchor cable and set sail, eventually arriving at Valparaiso, Chile, where they were brought into custody by the American consul, Michael Hogan.