Globidrillia smirna is a species of sea snail, a marine gastropod mollusk in the family Drilliidae.

[citation needed] The original description of the species was as follows: The long, slender shell shines with the lustre of barley-sugar candy.

The sculpture consisting of small pointed nodules set on the periphery of the whorls, a little in advance of midway between the sutures.

The tips of these nodules and a line just in advance of the suture are white as compared with the general translucent pinkish or fleshy hue.

The aperture is short and seemingly rather wide, behind.This species occurs in the demersal zone of the Caribbean Sea (Cuba) and the Gulf of Mexico at depths between 699 m and 755 m.[citation needed]