Found on the trunk of Eucalyptus trees in Cameroon, it is similar in appearance to Glyphis atrofusca but can be distinguished by these key characteristics.

The specific epithet, frischiana, was chosen to honour Dr. Andreas Frisch, an expert in Ostropales and Arthoniales, who collected the type during his PhD studies.

Ascospores are hyaline, becoming very slightly brownish with age, densely muriform, measuring 55–110 by 28–35 μm, and iodine-positive brownish-blue or violet-blue.

[2] Although it may easily be confused with a Graphis species, Glyphis frischiana can be distinguished by its brown, potassium hydroxide-negative epithecium and thick-walled paraphyses embedded in a jelly.

When compared to Graphis streblocarpa, Glyphis frischiana differs in the absence of a brown pruina, convergent labia, and a non-visible disc.