Gmina Dębno is an urban-rural gmina (administrative district) in Myślibórz County, West Pomeranian Voivodeship, in north-western Poland.

Its seat is the town of Dębno, which lies approximately 25 kilometres (16 mi) south-west of Myślibórz and 77 km (48 mi) south of the regional capital Szczecin.

The Barnówko-Mostno-Buszewo oil field is located in the gmina.

Apart from the town of Dębno, Gmina Dębno contains the villages and settlements of Barnówko, Bogusław, Borne, Borówno, Choszczówko, Cychry, Dargomyśl, Dolsk, Dyszno, Grzybno, Grzymiradz, Hajnówka, Juncewo, Klępin, Krężelin, Krześnica, Łazy, Młyniska, Mostno, Oborzany, Ostrowiec, Piołunek, Przylaszczka, Radzicz, Różańsko, Sarbinowo, Smolnica, Suchlica, Sulisław, Turze, Warnice and Więcław.

Gmina Dębno is bordered by the town of Kostrzyn nad Odrą and the gminas of Boleszkowice, Lubiszyn, Mieszkowice, Myślibórz and Trzcińsko-Zdrój.