Gmina Gryfino is an urban-rural gmina (administrative district) in Gryfino County, West Pomeranian Voivodeship, in north-western Poland, on the German border.

Its seat is the town of Gryfino, which lies approximately 20 kilometres (12 mi) south of the regional capital Szczecin.

The gmina contains parts of the protected areas of Szczecin Landscape Park and Lower Odra Valley Landscape Park.

Apart from the town of Gryfino, Gmina Gryfino contains the villages and settlements of Bartkowo, Borzym, Chlebowo, Chwarstnica, Ciosna, Czepino, Daleszewo, Dębce, Dołgie, Drzenin, Gajki, Gardno, Krajnik, Krzypnica, Łubnica, Mielenko Gryfińskie, Nowe Brynki, Nowe Czarnowo, Osuch, Parsówek, Pastuszka, Pniewo, Raczki, Radziszewo, Skrzynice, Sobiemyśl, Sobieradz, Śremsko, Stare Brynki, Steklinko, Steklno, Szczawno, Wełtyń, Wirów, Wirówek, Włodkowice, Wysoka Gryfińska, Żabnica, Zaborze, Żórawie and Żórawki.

Gmina Gryfino is bordered by the city of Szczecin and by the gminas of Banie, Bielice, Kołbaskowo, Stare Czarnowo and Widuchowa.