Gmina Kąkolewnica is a rural gmina (administrative district) in Radzyń Podlaski County, Lublin Voivodeship, in eastern Poland.

Its seat is the village of Kąkolewnica, which lies approximately 18 kilometres (11 mi) north of Radzyń Podlaski and 77 km (48 mi) north of the regional capital Lublin.

The gmina covers an area of 147.71 square kilometres (57.0 sq mi), and as of 2006 its total population is 8,459.

Gmina Kąkolewnica contains the villages and settlements of Brzozowica Duża, Brzozowica Mała, Grabowiec, Jurki, Kąkolewnica, Lipniaki, Miłolas, Mościska, Olszewnica, Polskowola, Sokule, Turów, Wygnanka, Żakowola Poprzeczna, Żakowola Radzyńska, Żakowola Stara and Zosinowo.

Gmina Kąkolewnica is bordered by the gminas of Drelów, Łuków, Międzyrzec Podlaski, Radzyń Podlaski, Trzebieszów and Ulan-Majorat.