Gmina Kamień Krajeński is an urban-rural gmina (administrative district) in Sępólno County, Kuyavian-Pomeranian Voivodeship, in north-central Poland.

Its seat in the historic Krajna region is the town of Kamień Krajeński, which lies approximately 10 kilometres (6 mi) north of Sępólno Krajeńskie and 56 km (35 mi) north-west of Bydgoszcz.

The gmina contains part of the protected area called Krajna Landscape Park.

Apart from the town of Kamień Krajeński, Gmina Kamień Krajeński contains the villages and settlements of Dąbrowa, Dąbrówka, Duża Cerkwica, Jakubowo, Jerzmionki, Mała Cerkwica, Niwy, Nowa Wieś, Obkas, Obkas-Młyn, Orzełek, Osady Zamerckie, Płocicz, Radzim, Witkowo and Zamarte.

Gmina Kamień Krajeński is bordered by the gminas of Chojnice, Człuchów, Debrzno, Kęsowo and Sępólno Krajeńskie.