Gmina Nowe Skalmierzyce is an urban-rural gmina (administrative district) in Ostrów Wielkopolski County, Greater Poland Voivodeship, in west-central Poland.

In 1999 the administrative seat of the gmina was moved from the town of Nowe Skalmierzyce to the adjoining locality of Skalmierzyce, which is officially classed as a village.

Skalmierzyce lies approximately 22 kilometres (14 mi) east of Ostrów Wielkopolski and 107 km (66 mi) south-east of the regional capital Poznań.

Apart from Skalmierzyce and Nowe Skalmierzyce, the gmina also contains the villages and settlements of Biskupice, Biskupice Ołoboczne, Boczków, Chotów, Czachory, Droszew, Fabianów, Gałązki Małe, Gałązki Wielkie, Głóski, Gniazdów, Gostyczyna, Kościuszków, Kotowiecko, Kurów, Leziona, Mączniki, Miedzianów, Ociąż, Osiek, Pawłów, Pawłówek, Śliwniki, Śmiłów, Strzegowa, Trkusów, Węgry and Żakowice.

Gmina Nowe Skalmierzyce is bordered by the city of Kalisz and by the gminas of Godziesze Wielkie, Gołuchów, Ostrów Wielkopolski and Sieroszewice.