Gmina Osie is a rural gmina (administrative district) in Świecie County, Kuyavian-Pomeranian Voivodeship, in north-central Poland.

The gmina covers an area of 209.61 square kilometres (80.9 sq mi), and as of 2006 its total population is 5,312.

The gmina contains part of the protected area called Wda Landscape Park.

Gmina Osie contains the villages and settlements of Brzeziny, Jaszcz, Łążek, Miedzno, Osie, Pruskie, Radańska, Stara Rzeka, Tleń, Wałkowiska and Wierzchy.

Gmina Osie is bordered by the gminas of Cekcyn, Drzycim, Jeżewo, Lniano, Osiek, Śliwice and Warlubie.