[1] Alexander biographer Richard Younger describes the song as taking "the moralistic view of a man who decides that it is wrong to romance his best friend's girl.

[3] Younger points out a number of similarities between "Go Home Girl" and Alexander's previous releases, including "sparse drum and piano figure," "choppy guitars," "off-beat cymbals" and "lush female vocals.

"[7] No Depression noted that despite not achieving the commercial success of "You Better Move On," "Go Home Girl" as well as "Anna" confirmed that his artistic talent hadn't diminished.

The friend tells her he is "trying to forget the things that we've done while Frank is just a-waiting back home", and he makes the decision: "Girl you can't go ride with me anymore; that's the way it's got to be from now on".

Gary U.S. Bonds and Frank Black performed the song as a duet on the 1994 album Adios Amigo: A Tribute to Arthur Alexander.