It is a subsidiary of the Go-Ahead Group, operating franchised Bee Network bus services on contract to Transport for Greater Manchester.

[1] Go North West commenced operations on 2 June 2019 following the Go-Ahead Group's purchase of First Greater Manchester's Queens Road depot with 163 vehicles.

Go North West took delivery of 50 Bee Network branded Alexander Dennis Enviro400EV battery electric buses for use on these services.

[9] As of 2024, the 41, 52, 53 and 135 are no longer operated by Go North West following the Queen's Road depot being taken over by Stagecoach Manchester as part of Tranche 2 of Bee Network bus franchising.

As of March 2024, Go North West operates 79 routes with a fleet of 340 buses, a large amount of which were initially acquired from First Greater Manchester in June 2019, with a large amount also acquired from Diamond Bus North West in September 2023 with the takeover of their Weston Street depot for Bee Network franchised services.

[15] On 28 February 2021, a strike was called by the union Unite over concerns that the new payment package was a 'fire and re-hire' scheme, following Go North West making a loss of £1.8 million per year.