Combining elements of political satire with dark humor, the film stars Joel Murray and Tara Lynne Barr as a middle-aged man and a teenage girl who go on a killing spree after bonding over their disgust of what American culture has become in a post-9/11 world.

Frank Murdoch is a middle-aged insurance salesman who is sick of how America has fallen into a state of depravity based on pop culture, TV, the Internet, and talk radio.

That evening, Frank watches television, and his attention is caught by American Superstarz, a talent show featuring an intellectually disabled man named Steven Clark, who the judges mock for his attempts at singing.

Frank explains that he only wants terrible people to die, and Roxy suggests they kill Chloe's parents, who only mourn the financial loss their daughter's death has brought them.

Frank and Roxy kill several more people, such as a rude man who double-parks his car, a group of far-right religious protesters, and a popular right-wing political commentator.

Frank buys an assault rifle from an arms dealer and sees another TV news report revealing that Roxy is back home with her parents and that police are searching for her apparent abductor.

Frank turns to Roxy and tells her that she is pretty—a question he had refused to answer earlier due to her young age—and the two shoot Steven, the judges, and various audience members before being gunned down by the police.

"[12] Ella Taylor of NPR gave a positive review, and wrote: "God Bless America ends with a couple of tale-twisting bullet orgies designed to take your preconceptions, as well as your nerve-endings, by surprise.