[7] Brigadier-General Alabi-Isama served as the commander of the troops stationed at the Niger Bridge in Asaba,[8] He was subsequently transferred by the Army Headquarters to the 3 Marina Commando, 3MCDO, operating on the Calabar front during the war.

[9][10] Alabi-Isama led forces against the Biafran Republic, successfully liberating various locations including Odukpani, Ikot-Okpora, Iwuru, Akunakuna, Itigidi, Ediba, Ugep, Obubra, Afikpo, Oban, and Ekang.

[11] In April 1968, Alabi-Isama and his 3MCDO men embarked on a mission to recapture Creek Town, Itu, Uyo, Ikot-Ekpene, Oron, Eket, Opobo, Abak, Etinan, Bori-Ogoni, Akwete, Afam, Aletu Ekene, Elelenwo, Okrika, and Port-Harcourt, successfully completing the operation the following month.

In 1973, he served as the Acting Governor of the Mid-Western Region, where he notably received the first group of National Youth Service Corps members, as recounted in his autobiography.

[13] Alabi-Isama played a pivotal role in leading the troops that successfully liberated the remaining parts of Cross River State following Colonel Adekunle's amphibious sea landing at Calabar.