Gonadarche

[1] In response to pituitary gonadotropins, the ovaries in females and the testes in males begin to grow and increase the production of the sex steroids, especially estradiol and testosterone.

[5] Puberty is influenced by a multitude of factors including genetic, prenatal, nutritional, and environmental status.

[7] Body weight and nutrition status is evidenced to have an effect on puberty onset as well, due to some input from adipose tissue hormonal signaling.

[6] Adrenarche is responsible for the maturation of the adrenal gland during puberty and stimulates the development of body odor, axillary hair, and acne.

[10] Gonadarche marks the beginning of puberty and it is the process in which gonads, or the primary reproductive organs, mature, following stimulation of gonadotropin hormone-releasing hormone (GnRH) release in the hypothalamus.

[12] Prior to onset of gonadarche, stimulation of these hormones from the hypothalamus is suppressed through GABAergic-releasing inhibitory neurons in the central nervous system.

Individuals with CPP will often experience an early growth spurt because their bones are maturing faster than usual.

However, since their growth plates will often close earlier and without proper treatment, children with CPP may not reach their predicted adult height.

CPP is caused by premature activation or incompletely suppressed hypothalamic GnRH(gonadotropin-releasing hormone) pulse generator.

Children with this condition undergo the typical stages of puberty, including the early development of reproductive organs, at younger ages than usual.

This is a rare condition with an estimated incidence of about 0.02 to 1.07 cases per million each year based on data collected from 2008 to 2010 in Spain.

These GnRH receptor agonists are available in the US as daily injections or less frequent depot forms, given every 28 days.

As a result, health professionals are rarely able to accurately predict the hight outcome of people with CPP.

However, there are other studies that counter act this claim and find no difference in the psychological outcomes in gris with CPP.

However, there have been laboratory studies done to differentiate a diagnosis of CDGP from Hypogonadotropic Hypogonadism using inhibin B and anti-Müllerian hormone concentrations.

In children with obesity, it may be harder to identify excess adipose tissue with bread bud development, leading to potential false early puberty diagnosis.

[24] In conclusion, starting treatment as early as right after diagnosis is related to significant success in maintaining final adult height in case of CPP.