The settlement is the oldest one in La Matanza County, and was founded in 1570 as a garrison by a Conquistador, Captain Juan de Garay.

The modern settlement originated with the 1869 sale of the land by Germán Carrizo to Dr. Mauricio González Catán, a prominent surgeon and provincial legislator.

Home to a dairy, an orchard and numerous other agricultural businesses, the town was established on April 3, 1910, by Dr. Enrique Simón Pérez, a dentist and brother-in-law of González Catán.

It social problems increased as well, however, and the city was the site of Father Mario Pantaleo's chapel and day care center from the 1970s onwards.

Begun by local businessman Antonio Campana in 1976, Campanópolis was built on a former dump site in a Gothic style reminiscent of a Tim Burton film set and occupies 200 hectares (490 acres) east of Route 3.