Like the novel, Good Omens features various Christian themes and figures and follows various characters all trying to either encourage or prevent an imminent Armageddon, seen through the eyes of the angel Aziraphale and the demon Crowley.

The first series follows the demon Crowley (David Tennant) and the angel Aziraphale (Michael Sheen), longtime acquaintances who have grown accustomed to each other's company, and to a pleasant life on Earth in the present day as representatives of Heaven and Hell, and who have agreed not to let the conflict between their sides prevent their friendship.

When told that Armageddon is about to happen – the final battle between Heaven and Hell – they team up to prevent the coming of the Antichrist and the end of the pleasant existence they enjoy on Earth.

[9][10] Executive producers were set to include Gaiman, Caroline Skinner, Chris Sussman, Rob Wilkins, and Rod Brown.

[12] Gaiman's initial writing around the announcement of season two mentioned the proposed sequel to Good Omens devised by him and Terry Pratchett during the World Science Fiction Convention in Seattle in 1989, the year before the book was published.

[20] In October 2024, Gaiman officially exited the project and production of the third series was reduced from a full season order to a single 90-minute episode.

[22] On 14 September 2017, Gaiman revealed on Twitter that Nina Sosanya, Ned Dennehy, and Ariyon Bakare had joined the main cast.

[25] In October 2017, it was reported that Jon Hamm, Anna Maxwell Martin, Mireille Enos, Lourdes Faberes, and Yusuf Gatewood had joined the main cast.

[32] On 20 July 2018, it was announced during Amazon's San Diego Comic-Con panel that Frances McDormand had been cast as the voice of God as well as the series' narrator.

[40] Good Omens' opening title sequence, created by the London-based Peter Anderson Studio, features music by David Arnold.

[43][44] The actual production used physical props, animation, illustration, 3D and some live-action motion, to depict the approaching apocalypse and clash between Heaven and Hell.

[43] Included are Crowley's Bentley in front of Aziraphale's bookshop, the Chattering Order of St. Beryl's nuns, Shadwell and Madame Tracy, the hellhound, flying saucers, the appearance of Death, and the Four Horsemen of the Apocalypse.

[49] His off-white colour palette and style maintained a Victorian Era look through modern times, with oversized lapels and shoulders representing his Angel wings.

"Flowing gowns" and colours reflecting "kookiness" were used for her mystic persona, while an ostentatious kimono represented her "lady of the night" role.

[51] The cold opening, featuring a flashback through history in Episode 3, required costumes representing historical periods from the Garden of Eden in 4004 BC to Soho, London in 1967.

[35] The escalator to Hell was filmed in a modern office building in London using real-time cinematography as well as a green screen for special effects depicting Crowley's descent from the lobby.

[57] Episode 4 featured a visual effect of Crowley (David Tennant) flying through the telephone system, chased by Hastur, the Duke of Hell (Ned Dennehy).

[39] Rather than using digital effects to create the scenery as Crowley is driving, director of photography Gavin Finney used an older technique called rear projection.

Finney explained: "It means you see the footage as well as reflections on the glass or the driver's face, say as the vehicle goes under trees, while it also works as a lighting source.

The original concept of Satan was much more "hellish"; however, Neil Gaiman wanted a more human form of the 500-foot-tall creature, rather than including "hellfire" and over-the-top demonic action.

[55] Good Omens features music written by Emmy winning composer David Arnold, along with quite a few Queen songs throughout the series.

[67][68] David Tennant and Michael Sheen reprised their respective roles in voice-only form for a 3-minute short titled "Good Omens: Lockdown" which was released on YouTube on 1 May 2020.

It was moderated by Whoopi Goldberg and featured creator Neil Gaiman, director Douglas Mackinnon, and cast members Michael Sheen, David Tennant, Jon Hamm and Miranda Richardson.

[72][73] AT SXSW 2019, Amazon Prime hosted a Good Omens "Garden of Eden" Party in Austin, Texas during the entire week of the festival.

The party was hosted by performers dressed as angels and demons, with free food, hair and nail services, and a complimentary bar.

David Tennant, Michael Sheen, Jon Hamm, Douglas Mackinnon and Neil Gaiman made guest appearances, and an episode of the series received an early screening at the Zach Theatre.

Good Omens-branded umbrellas and tote bags were handed out at the pop-up experience, and the Garden featured a petting zoo full of local puppies called "Hell Hounds".

The website's critical consensus reads, "A smörgåsbord of heavenly imagery and irreverent hilarity, Good Omens works thanks to Michael Sheen and David Tennant's very-nearly-holy (or maybe unholy?)

[78] An online petition erroneously requesting that Netflix cancel Good Omens reportedly received more than 20,000 signatures from people objecting to its content, perhaps unaware that it was actually on Amazon and had already been released in full.

The petition, posted as part of a campaign by US religious organization Return to Order, criticized the show's irreverent treatment of topics relating to Satanism and the devil, and the use of a female voice for God.