Goose Creek is the most populous city in Berkeley County in the U.S. state of South Carolina.

In the 1670s the Etiwan moved to the area to escape the Westo, seeking protection among the plantations of early colonists who were often referred to as the "Goose Creek men", mostly settled a few miles north of Charleston near a stream called Goose Creek, a tributary of the Cooper River.

The Goose Creek men became leaders of the early Indian trade, and by the 1690s many held important offices in the colonial government.

[11] The Otranto Plantation Indigo Vats and St. James Church are listed on the National Register of Historic Places.

During the Cold War, the Naval Base (1902–1996) became the third largest U.S. homeport serving over 80 ships and submarines.

In addition, the Charleston Naval Shipyard repaired frigates, destroyers, cruisers, sub tenders, and submarines.

During this period, the Weapons Station was the Atlantic Fleet's loadout base for all nuclear ballistic missile submarines.

At the 1996 closure of the Station's Polaris Missile Facility Atlantic (POMFLANT), over 2,500 nuclear warheads and their UGM-27 Polaris, UGM-73 Poseidon, and UGM-96 Trident I delivery missiles (SLBM) were stored and maintained, guarded by a U.S. Marine Corps security force company.

Today, Joint Base Charleston, encompassing over 20,877 acres (8,449 ha) and supporting 53 military commands and federal agencies, provides service to over 79,000 airmen, sailors, soldiers, Marines, Coast Guardsmen, DOD civilians, dependents, and retirees.